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ea0086p94 | Neuroendocrinology and Pituitary | SFEBES2022

Gene-chromatin regulatory circuits driving stemness in the anterior pituitary

Yianni Val , Lodge Emily J. , Willis Thea L. , Kemkem Yasmine , Zamojski Michel , Mendelev Natalia , Sealfon Stuart C. , Ruf-Zamojski Frederique , Andoniadou Cynthia L.

The pituitary gland is a dynamic organ that adapts its cellular architecture throughout life, making it an ideal model for the study of stem cells (SCs), their commitment and differentiation. Sox2-expressing cells are bona fide anterior pituitary stem cells (PSCs), which through genetic lineage tracing have been shown to give rise to all anterior pituitary hormone-producing cells both in the embryo and adult. The YAP/TAZ signalling pathway has been previously...

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ea0090p425 | Pituitary and Neuroendocrinology | ECE2023

Longitudinal multiomics characterization of paired primary and recurrent aggressive pituitary tumors from the same patient reveals genomic stability and transcriptomic and epigenetic heterogeneity with metabolic pathways alterations

Taniguchi Keiko , Chavez-Santoscoy Alejandra , Hinojosa-Alvarez Silvia , Hernandez-Perez Jesus , Valenzuela-Perez Alejandra , Vela Patino Sandra , Andonegui-Elguera Sergio , Cano-Zaragoza Amayrani , Martinez Florencia , Kerbel Jacobo , Zhang Zidong , Smith Gergory , Rubenstein Aliza , Sze Cheng Wan , Mendelev Natalia , Anne Amper Mary , Zamojski Michel , Zaslavsky Elena , Ruf-Zamojski Frederique , Sealfon Stuart , Mercado Moises , Marrero-Rodriguez Daniel

Pituitary tumors (PT) represent 20% of all intracranial neoplasms. Some behave aggressively, growing rapidly and invading surrounding tissues, with high recurrence rates and are frequently resistant to conventional therapies. We performed exome and transcriptome sequencing, as well as methylation profiling of primary and recurrent PT of the same patient. The cohort consisted of patients with GH- and gonadotropin-producing PT and a patient with an ACTH carcinom...

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Endocrine Abstracts

Gene-chromatin regulatory circuits driving stemness in the anterior pituitary

Longitudinal multiomics characterization of paired primary and recurrent aggressive pituitary tumors from the same patient reveals genomic stability and transcriptomic and epigenetic heterogeneity with metabolic pathways alterations

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